Gestational diabesity and foetoplacental vascular dysfunction

Gestational diabetes mellitus (GDM) shows a deficiency in the metabolism of D-glucose and other nutrients, thereby negatively affecting foetoplacental vascular endothelium. Maternal hyperglycaemia hyperinsulinemia play an important role aetiology GDM. A combination these factors predisposes women to developing GDM with pre-pregnancy normal weight, viz. classic However, prepregnancy obesity (gestational diabesity, GDty) or overweight (GDMow) show different metabolic status than GDty GDMow are associated altered l-arginine/nitric oxide insulin/adenosine axis signalling human microvascular macrovascular These alterations differ from those observed Here, we have reviewed consequences modulation endothelial cell function, highlighting studies describing intracellular pH homeostasis potential implications NO generation adenosine GDty-associated foetal insulin resistance. Moreover, increase rate childbearing age worldwide, prevalence is expected next decades. Therefore, emphasize that should be characterized state develop more specific therapeutic approach for protecting mother foetus.